Off label indications for atypical antipsychotics a systematic review konstantinos n fountoulakis 1 ioannis nimatoudis 1 apostolos iacovides 1 and george kaprinis 1 the current review suggests that there are some evidence that support the usefulness of atypical antipsychotics in some off label situations the generalization of these . Effectiveness benefits and adverse effects of atypical antipsychotics for off label indications in adults this summary is based on a systematic review that includes 170 studies of efficacy or comparative effectiveness and 180 studies reporting adverse. Although the recommendation to use atypical antipsychotics in a variety of off label situations is widespread in the literature the current review proved that data are few and can not really support an evidence based recommendation. Four non systematic narrative reviews have been conducted to evaluate the efficacy of quetiapine for insomnia and one 2011 systematic review investigated atypical antipsychotics for various off label indications non systematic narrative reviews may provide a good overview of the topic yet non systematic searches increase the . A 2007 study on efficacy and comparative effectiveness of off label use of atypical antipsychotics reviewed the scientific evidence on the safety and effectiveness for off label uses of these drugs 1 the study examined 84 published studies on atypical antipsychotics and found that the most common off label uses of the drugs were treatment of
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