Neurodegenerative diseases are a large group of disabling disorders of the nervous system characterized by the relative selective death of neuronal subtypes in most cases there is overwhelming evidence of impaired mitochondrial function as a causative factor in these diseases more recently . Mitochondrial dysfunctions are supposed to be responsible for many neurodegenerative diseases dominating in alzheimers disease ad parkinsons disease pd and huntingtons disease hd a growing body of evidence suggests that defects in mitochondrial metabolism and particularly of electron transport chain may play a role in pathogenesis of ad. Mitochondria oxidative stress and neurodegeneration in primary mitochondrial and neurodegenerative disorders there is strong evidence that mitochondrial dysfunction occurs early and has a primary role in pathogenesis in the present review we discuss several mitochondrial diseases as models of neurodegeneration . Mitochondria play a pivotal role in several functional processes in neurons from biogenesis to cell death which are co dependent and interrelated mitochondrial dysfunction has been implicated in the pathogenesis of many neurodegenerative disorders including parkinsons disease pd alzheimers
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